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KMID : 0615720090260040099
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Jouranl of Korean Acupuncture and Moxibustion society
2009 Volume.26 No. 4 p.99 ~ p.106
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Antidepressant Effect of the Subchronic Administration of the Methanolic Extract of Wild-ginseng and Cultivated-ginseng in Mice Tail Suspension Test
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Kwon Sun-Oh
Hahm Dae-Hyun
Park Hi-Joon
Lee Hye-Jung
Choi Soo-Min
Kim Myung-Hwan
Lee Bom-Bi
Park Moo-Won
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Abstract
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Objectives : The antidepressant effect of the subchronic administration of the methanolic extract of wild?ginseng(WG) was investigated compared with that of cultivated ginseng(CG, panax ginseng) extract.
Methods : To assess the antidepressant effect of the ginseng extracts, tail suspension test(TST) was executed in mice after daily administration of WG or CG extract for five consecutive days.
Results : The WG extract at daily dose of 600mg/kg significantly reduced the total duration of immobility in the TST, whereas there was no significant reduction at daily dose of 300mg/kg WG and 600mg/kg CG. There were no individual differences between experimental groups in open field test (OFT) to evaluate psychostimulant effects of WG or CG extract. In the high performance liquid chromatography(HPLC) analysis of the extracts, it was found that WG included four times more ginsenoside Rg1 and Re, three times more Rf, and six times more Rb1 and Rc than CG.
Conclusions : It is suggested that WG extract has stronger antidepressant effect than CG extract, which means it includes more antidepressant compounds than CG.
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KEYWORD
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panax ginseng, wild-ginseng, antidepressant, tail suspension test
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